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1

Activation of complement by monoclonal antibodies that target cell-associated β2-microglobulin: Implications for cancer immunotherapy

Pokrass, Michael J., Liu, Monica F., Lindorfer, Margaret A., Taylor, Ronald P.

Journal:

Molecular Immunology

Year:

2013

Language:

english

File:

PDF, 2.13 MB

english, 2013

2

The role of complement in mAb-based therapies of cancer

Taylor, Ronald P., Lindorfer, Margaret A.

Journal:

Year:

2014

Language:

english

File:

PDF, 406 KB

english, 2014

3

Antibody Fc || Interactions Between the Complement System and Fcγ Receptors

Lindorfer, Margaret A.

Year:

2014

Language:

english

File:

PDF, 1.49 MB

english, 2014

4

Cytotoxic mechanisms of immunotherapy: Harnessing complement in the action of anti-tumor monoclonal antibodies

Taylor, Ronald P., Lindorfer, Margaret A.

Journal:

Seminars in Immunology

Year:

2016

Language:

english

File:

PDF, 1019 KB

english, 2016

5

Mutations and protein stability

John A. Schellman, Margaret Lindorfer, Richard Hawkes, Markus Grutter

Journal:

Year:

1981

Language:

english

File:

PDF, 611 KB

english, 1981

6

Penetration of antibody-opsonized cells by the membrane attack complex of complement promotes Ca2+ influx and induces streamers

Paul V. Beum, Margaret A. Lindorfer, Elizabeth M. Peek, P. Todd Stukenberg, Michel de Weers, Frank J. Beurskens, Paul W. H. I. Parren, Jan G. J. van de Winkel, Ronald P. Taylor

Journal:

European Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 378 KB

english, 2011

7

Staphylococcus aureus bound to complement receptor 1 on human erythrocytes by bispecific monoclonal antibodies is phagocytosed by acceptor macrophages

Edit Gyimesi, Alexander J. Bankovich, Theodore A. Schuman, Joanna B. Goldberg, Margaret A. Lindorfer, Ronald P. Taylor

Journal:

Immunology Letters

Year:

2004

Language:

english

File:

PDF, 225 KB

english, 2004

8

Heteropolymer-mediated clearance of immune complexes via erythrocyte CR1: mechanisms and applications

Margaret A. Lindorfer, Chang S. Hahn, Patricia L. Foley, Ronald P. Taylor

Journal:

Immunological Reviews

Year:

2001

Language:

english

File:

PDF, 415 KB

english, 2001

9

Targeting of cancer cells with monoclonal antibodies specific for C3b(i)

Mitchell H. Sokoloff, Alessandra Nardin, Michael D. Solga, Margaret A. Lindorfer, William M. Sutherland, Alexander J. Bankovich, Haiyen E. Zhau, Leland W. K. Chung, Ronald P. Taylor

Journal:

Cancer Immunology, Immunotherapy

Year:

2000

Language:

english

File:

PDF, 427 KB

english, 2000

10

Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies

Ronald P Taylor, Margaret A Lindorfer

Journal:

Current Opinion in Immunology

Year:

2008

Language:

english

File:

PDF, 364 KB

english, 2008

11

Impact of low-dose rituximab on splenic B cells: evidence for the shaving reaction

Ronald P. Taylor, Margaret A. Lindorfer

Journal:

Transplant International

Year:

2010

Language:

english

File:

PDF, 140 KB

english, 2010

12

Quantitative analysis of protein co-localization on B cells opsonized with rituximab and complement using the ImageStream multispectral imaging flow cytometer

Paul V. Beum, Margaret A. Lindorfer, Brian E. Hall, Thaddeus C. George, Keith Frost, Philip J. Morrissey, Ronald P. Taylor

Journal:

Journal of Immunological Methods

Year:

2006

Language:

english

File:

PDF, 979 KB

english, 2006

13

Complement-dependent lysis of mAb-opsonized B cells can increase resistance of naïve B cells to subsequent attack by mAb and complement

Ronald P. Taylor, Paul V. Beum, Margaret A. Lindorfer, Andrew W. Pawluzckowycz, Frank J. Beurskens, Jan G.J. van de Winkel, Paul W.H.I. Parren

Journal:

Molecular Immunology

Year:

2010

Language:

english

File:

PDF, 71 KB

english, 2010

14

The monoclonal antibody, 3E7, is a multi-functional inhibitor of the alternative pathway that blocks NeF-triggered activation

Danielle Paixao-Cavalcante, Margaret A. Lindorfer, B. Paul Morgan, Ronald P. Taylor, Claire L. Harris

Journal:

Molecular Immunology

Year:

2010

Language:

english

File:

PDF, 74 KB

english, 2010

15

A bispecific dsDNA×monoclonal antibody construct for clearance of anti-dsDNA IgG in systemic lupus erythematosus

Margaret A. Lindorfer, Theodore A. Schuman, Maria L. Craig, Edward N. Martin, Ronald P. Taylor

Journal:

Journal of Immunological Methods

Year:

2001

Language:

english

File:

PDF, 676 KB

english, 2001

16

Concerted clearance of immune complexes bound to the human erythrocyte complement receptor: development of a heterologous mouse model

Andrea L Henderson, Margaret A Lindorfer, Adam D Kennedy, Patricia L Foley, Ronald P Taylor

Journal:

Journal of Immunological Methods

Year:

2002

Language:

english

File:

PDF, 531 KB

english, 2002

17

Purification of all thirteen polypeptides of bovine heart cytochrome c oxidase from one aliquot of enzyme Characterization of bovine fetal heart cytochrome c oxidase

Shinzaburo Takamiya, Margaret A. Lindorfer, Roderick A. Capaldi

Journal:

Year:

1987

Language:

english

File:

PDF, 632 KB

english, 1987

18

Selective and efficient inhibition of the alternative pathway of complement by a mAb that recognizes C3b/iC3b

David J. DiLillo, Andrew W. Pawluczkowycz, Wu Peng, Adam D. Kennedy, Paul V. Beum, Margaret A. Lindorfer, Ronald P. Taylor

Journal:

Molecular Immunology

Year:

2006

Language:

english

File:

PDF, 511 KB

english, 2006

19

Low doses of antigen coupled to anti-CR2 mAbs induce rapid and enduring IgG immune responses in mice and in cynomolgus monkeys

Emily C. Whipple, Andrew H. Ditto, Ryan S. Shanahan, Jeremy J. Gatesman, Stephen F. Little, Ronald P. Taylor, Margaret A. Lindorfer

Journal:

Molecular Immunology

Year:

2007

Language:

english

File:

PDF, 1.89 MB

english, 2007

20

Hematin promotes complement alternative pathway-mediated deposition of C3 activation fragments on human erythrocytes: Potential implications for the pathogenesis of anemia in malaria

Ronald P. Taylor, Andrew W. Pawluczkowycz, Margaret A. Lindorfer, John W. Waitumbi

Journal:

Molecular Immunology

Year:

2007

Language:

english

File:

PDF, 50 KB

english, 2007

21

How are immune complexes bound to the primate erythrocyte complement receptor transferred to acceptor phagocytic cells?

Alessandra Nardin, Margaret A Lindorfer, Ronald P Taylor

Journal:

Molecular Immunology

Year:

1999

Language:

english

File:

PDF, 195 KB

english, 1999

22

Antigenic Modulation and Rituximab Resistance

Ronald P. Taylor, Margaret A. Lindorfer

Journal:

Seminars in Hematology

Year:

2010

Language:

english

File:

PDF, 247 KB

english, 2010

23

CD20 mAb-mediated C3b deposition and complement dependent cytotoxicity of tumor cells is enhanced by blocking the action of Factor I

Ronald P. Taylor, Margaret A. Lindorfer, Paul V. Beum

Journal:

Year:

2012

Language:

english

File:

PDF, 68 KB

english, 2012

24

5.15 Resistance to Complement-Dependent Cytotoxicity in Chronic Lymphocytic Leukemia Cells from Patients Treated with Ofatumumab

Nisar A. Baig, Ronald P. Taylor, Margaret A. Lindorfer, Amy K. Church, Betsy R. LaPlant, Emily S. Pavey, Tait D. Shanafelt, Timothy G. Call, Neil E. Kay, Grzegorz S. Nowakowski, Clive S. Zent

Journal:

Clinical Lymphoma Myeloma and Leukemia

Year:

2011

Language:

english

File:

PDF, 217 KB

english, 2011

25

Drug Insight: the mechanism of action of rituximab in autoimmune disease—the immune complex decoy hypothesis

Taylor, Ronald P, Lindorfer, Margaret A

Journal:

Nature Clinical Practice Rheumatology

Year:

2007

Language:

english

File:

PDF, 351 KB

english, 2007

26

Mechanisms of enhanced neutralization of botulinum neurotoxin by monoclonal antibodies conjugated to antibodies specific for the erythrocyte complement receptor

Sharma, Rashmi, Zhao, Huiwu, Al-Saleem, Fetweh H., Ubaid, Ahmed Syed, Puligedda, Rama Devudu, Segan, Andrew T., Lindorfer, Margaret A., Bermudez, Rodney, Elias, Md., Adekar, Sharad P., Simpson, Lance

Journal:

Molecular Immunology

Year:

2014

Language:

english

File:

PDF, 1.45 MB

english, 2014

27

Orientation of the cytoplasmically made subunits of beef heart cytochrome c oxidase determined by protease digestion and antibody binding experiments

Zhang, Yu Zhong, Lindorfer, Margaret A., Capaldi, Roderick A.

Journal:

Year:

1988

Language:

english

File:

PDF, 2.67 MB

english, 1988

28

Complement dependent cytotoxicity in chronic lymphocytic leukemia: ofatumumab enhances alemtuzumab complement dependent cytotoxicity and reveals cells resistant to activated complement

Baig, Nisar A., Taylor, Ronald P., Lindorfer, Margaret A., Church, Amy K., Laplant, Betsy R., Pavey, Emily S., Nowakowski, Grzegorz S., Zent, Clive S.

Journal:

Leukemia and Lymphoma

Year:

2012

Language:

english

File:

PDF, 436 KB

english, 2012

29

Kinetic and equilibrium studies of concanavalin A activation by calcium ions

Sherry, A. Dean, Lindorfer, Margaret A., Adams-Stemler, Patrick, Milanes, Oscar A.

Journal:

Year:

1981

Language:

english

File:

PDF, 1008 KB

english, 1981

30

Subunit arrangement in beef heart complex III

Gonzalez-Halphen, Diego, Lindorfer, Margaret A., Capaldi, Roderick A.

Journal:

Year:

1988

Language:

english

File:

PDF, 5.92 MB

english, 1988

31

Reconstitution of Bovine A 1 Adenosine Receptors and G Proteins in Phospholipid Vesicles: βγ-Subunit Composition Influences Guanine Nucleotide Exchange and Agonist Binding †

Figler, Robert A., Lindorfer, Margaret A., Graber, Stephen G., Garrison, James C., Linden, Joel

Journal:

Year:

1997

Language:

english

File:

PDF, 326 KB

english, 1997

32

Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells

Zent, Clive S., Taylor, Ronald P., Lindorfer, Margaret A., Beum, Paul V., LaPlant, Betsy, Wu, Wenting, Call, Timothy G., Bowen, Deborah A., Conte, Michael J., Frederick, Lori A., Link, Brian K., Black

Journal:

American Journal of Hematology

Year:

2014

Language:

english

File:

PDF, 625 KB

english, 2014

33

CD20 mAb-Mediated Complement Dependent Cytotoxicity of Tumor Cells is Enhanced by Blocking the Action of Factor I

Lindorfer, Margaret, Beum, Paul, Taylor, Ronald

Journal:

Year:

2013

Language:

english

File:

PDF, 434 KB

english, 2013

34

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

van den Bremer, Ewald TJ, Beurskens, Frank J, Voorhorst, Marleen, Engelberts, Patrick J, de Jong, Rob N, van der Boom, Burt G, Cook, Erika M, Lindorfer, Margaret A, Taylor, Ronald P, van Berkel, Patri

Journal:

Year:

2015

Language:

english

File:

PDF, 887 KB

english, 2015

35

Monoclonal Antibodies: New Therapeutic Agents for Autoimmune Hemolytic Anemia?

D'Arena, Giovanni, Taylor, Ronald, Cascavilla, Nicola, Lindorfer, Margaret

Journal:

Endocrine Metabolic & Immune Disorders - Drug Targets

Year:

2008

Language:

english

File:

PDF, 192 KB

english, 2008

36

Monoclonal antibody (mAb)-based cancer therapy

Lindorfer, Margaret A., Wiestner, Adrian, Zent, Clive S., Taylor, Ronald P.

Journal:

Year:

2012

Language:

english

File:

PDF, 832 KB

english, 2012

37

Real-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells

Lindorfer, Margaret A., Cook, Erika M., Tupitza, Jillian C., Zent, Clive S., Burack, Richard, de Jong, Rob N., Beurskens, Frank J., Schuurman, Janine, Parren, Paul W.H.I., Taylor, Ronald P.

Journal:

Molecular Immunology

Year:

2016

Language:

english

File:

PDF, 4.22 MB

english, 2016

38

Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia

Lindorfer, Margaret A., Cook, Erika M., Reis, Edimara S., Ricklin, Daniel, Risitano, Antonio M., Lambris, John D., Taylor, Ronald P.

Journal:

Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 835 KB

english, 2016

39

Antibodies that efficiently form hexamers upon antigen binding can induce complement-dependent cytotoxicity under complement-limiting conditions

Taylor, Ronald P., Lindorfer, Margaret A., Cook, Erika M., Beurskens, Frank J., van der Horst, Hilma, Oostindie, Simone, Schuurman, Janine, Zent, Clive, Burack, Richard, Parren, Paul W.H.I.

Journal:

Year:

2016

Language:

english

File:

PDF, 54 KB

english, 2016

40

NIH Public Access

Diebolder, Christoph A, Beurskens, Frank J, Jong, Rob N De, Koning, Roman I, Strumane, Kristin, Lindorfer, Margaret A, Voorhorst, Marleen, Ugurlar, Deniz, Heck, Albert J R, Winkel, Jan G J Van De, Wil

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

41

Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9

Taylor, Ronald P., Lindorfer, Margaret A., Cook, Erika M., Beurskens, Frank J., Schuurman, Janine, Parren, Paul W.H.I., Zent, Clive S., VanDerMeid, Karl R., Burack, Richard, Mizuno, Masashi, Paul Morg

Journal:

Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 534 KB

english, 2017

42

Complement C5a-induced changes in neutrophil morphology during inflammation

Denk, Stephanie, Taylor, Ronald P., Wiegner, Rebecca, Cook, Erika M., Lindorfer, Margaret A., Pfeiffer, Katharina, Paschke, Stephan, Eiseler, Tim, Weiss, Manfred, Barth, Eberhard, Lambris, John D., Ka

Journal:

Scandinavian Journal of Immunology

Year:

2017

Language:

english

File:

PDF, 1.29 MB

english, 2017

43

Activation of alternative complement pathway without complement factor D

Zhang, Yuzhou, Keenan, Adam, Lindorfer, Margaret A., Pitcher, Gabriella R., Taylor, Ronald P., Lambris, John D., Smith, Richard J.H.

Journal:

Molecular Immunology

Year:

2017

Language:

english

File:

PDF, 48 KB

english, 2017

44

Mechanisms of complement-mediated damage in hematological disorders

Taylor, Ronald P., Lindorfer, Margaret A.

Journal:

Seminars in Hematology

Year:

2018

Language:

english

File:

PDF, 432 KB

english, 2018

45

Hexamerization-enhanced CD37 and CD20 antibodies synergize in CDC to kill patient-derived CLL cells with unprecedented potency

Taylor, Ronald, Lindorfer, Margaret, Oostindie, Simone, Cook, Erika, Zent, Clive, Burack, Richard, Beurskens, Frank, Schuurman, Janine, Breij, Esther, Parren, Paul

Journal:

Molecular Immunology

Year:

2018

Language:

english

File:

PDF, 46 KB

english, 2018

46

Endothelial microparticles and complement activation in patients with chronic kidney disease

Renner, Brandon, Jalal, Diana, Laskowski, Jennifer, Stites, Erik, Lindorfer, Margaret, Taylor, Ronald, Holers, V. Michael, Thurman, Joshua

Journal:

Molecular Immunology

Year:

2018

Language:

english

File:

PDF, 47 KB

english, 2018

47

Critical role of C5a in sickle cell disease

Vercellotti, Gregory M., Dalmasso, Agustin P., Schaid, Terry R., Nguyen, Julia, Chen, Chunsheng, Ericson, Marna E., Abdulla, Fuad, Killeen, Trevor, Lindorfer, Margaret A., Taylor, Ronald P., Belcher,

Journal:

American Journal of Hematology

Year:

2018

Language:

english

File:

PDF, 2.61 MB

english, 2018

48

CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

Oostindie, Simone C., van der Horst, Hilma J., Lindorfer, Margaret A., Cook, Erika M., Tupitza, Jillian C., Zent, Clive S., Burack, Richard, VanDerMeid, Karl R., Strumane, Kristin, Chamuleau, Martine

Journal:

Year:

2019

Language:

english

File:

PDF, 3.08 MB

english, 2019

49

Clearance of amyloidâbeta with bispecific antibody constructs bound to erythrocytes

Taylor, Ronald P., Lindorfer, Margaret A., Atkinson, John P.

Journal:

Alzheimer s & Dementia Translational Research & Clinical Interventions

Year:

2020

File:

PDF, 375 KB

2020

50

How Do mAbs Make Use of Complement to Kill Cancer Cells? The Role of Ca2+

Taylor, Ronald P., Lindorfer, Margaret A.

Journal:

Year:

2020

File:

PDF, 9.23 MB

2020